Lee Sheldon took his Multiplayer Game Design course and turned it into an online game for his students:

Course format: The class itself will be structured as an online game with students dividing into guilds, then leveling up by earning XP through quests, raids and crafting which include presentations, quizzes and written work. The final guild projects are concept documents for online games and virtual worlds.

Anecdotally, attendance and other metrics of student performance went up. Time for some experiments.... ;)